About M.E.

I'm a PhD student working with Dr. Wilma K. Olson at the Biopolymer Structure Laboratory in understanding RNA Conformations, Motifs, and Folds at the nucleotide base step level using a rigid body parameter formalism implemented in the 3DNA (source, web interface) software package.

Our current work is focused on three main projects:
a) Development of a rigid body formalism for RNA helical regions implemented in C++.
b) Sequence dependent deformability of RNA helical regions (Including non-canonical Watson-Crick base-pairing interactions). Such work can be quite useful for obtaining accurate models of small helical RNA's, for example microRNA's.
c) Automatic classification of the space of RNA base-pairs, and base-steps parameters using clustering analysis techniques.

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